Table 3.

CARGO II GEP test performance results in the ≥2–6 months post-transplantation period

GEP score	Scores below threshold n (%)	PPV (%)	NPV (%)	Sensitivity (%)	Specificity (%)
12	14 (2.9)	1.9	100.0	100.0	3.5
13	21 (4.4)	2.0	100.0	100.0	5.0
14	31 (6.5)	2.0	100.0	100.0	7.1
15	39 (8.1)	2.1	100.0	100.0	9.3
16	50 (10.4)	2.1	100.0	100.0	11.7
17	58 (12.1)	2.1	100.0	100.0	13.3
18	71 (14.8)	2.1	99.4	95.0	15.9
19	83 (17.3)	2.0	99.0	90.0	17.9
20	95 (19.8)	2.0	98.8	87.5	20.2
21	111 (23.1)	2.1	99.0	87.5	23.9
22	133 (27.7)	2.3	99.2	87.5	28.2
23	155 (32.3)	2.1	98.7	77.5	32.7
24	182 (37.9)	2.0	98.3	65.0	38.0
25	201 (41.9)	2.1	98.4	65.0	42.0
26	223 (46.5)	2.1	98.4	60.0	47.2
27	256 (53.3)	2.1	98.3	52.5	53.6
28	295 (61.5)	2.1	98.3	42.5	61.9
29	321 (66.9)	2.1	98.3	37.5	67.3
30	349 (72.7)	2.6	98.4	37.5	73.2
31	373 (77.7)	3.1	98.5	37.5	77.7
32	393 (81.9)	3.1	98.4	30.0	81.9
33	409 (85.2)	3.9	98.5	30.0	85.8
34	425 (88.5)	4.0	98.4	25.0	88.7
35	443 (92.3)	2.3	98.2	10.0	91.9
36	453 (94.4)	3.1	98.2	10.0	94.1
37	460 (95.8)	4.2	98.2	10.0	95.6
38	475 (99.0)	0.0	98.1	0.0	98.9
39	479 (99.8)	0.0	98.1	0.0	99.7

GEP test scores range from 0 to 39.

CARGO, Cardiac Allograft Rejection Gene Expression Observational Study; GEP, gene-expression profiling; NPV, negative predictive value; PPV, positive predictive value.