Table 2.
Photodynamic therapy studies for advanced non-small cell lung cancer in the last 10 years
| Publication | Indication | Photosensitizer | No. of Patients | Outcome | Comments |
|---|---|---|---|---|---|
| Ross et al., 2006 (30) | IIA–IIIB | Porfimer sodium | 41 | PR: 100% | Induction PDT: PDT alone, PDT with Chemo and/or RT followed by surgery |
| Weinberg et al., 2010 (29) | IA, IIA, III, IV | Porfimer sodium | 9 | Local tumor control: 78% | Combined PDT and HDR |
| Ji et al., 2013 (33) | IIIA | Radachlorin | 10 | CR: 20%, PR: 70% | PDT as unique treatment modality |
| Akopov et al., 2013 (32) | IIIA and IIIB | Radachlorin | 20 | PR: 100% | Induction PDT with Chemo, followed by surgery and intraoperative PDT of the resection margins |
| Akopov et al., 2013 (31) | II–III | Radachlorin | 22 | PR: 95% | Induction PDT with Chemo, followed by surgery and intraoperative PDT of the resection margins |
| Akopov et al., 2014 (37) | IIIA and IIIB | Radachlorin | 21 | PR: 90%/76% (with/without PDT) | Prospective randomized study: Induction Chemo with PDT compared with Chemo alone, followed by surgery |
Definition of abbreviations: CR = complete response; Chemo = chemotherapy; HDR = high-dose-rate brachytherapy; PDT = photodynamic therapy; PR = partial response; RT = radiotherapy.