Table 1.
Baseline characteristics of the Multicenter International Lymphangioleiomyomatosis Efficacy and Safety of Sirolimus computed tomography cohort
| Variable | Placebo (n = 14) | Sirolimus (n = 17) | P Value | |
|---|---|---|---|---|
| Age, yr |
43 (35–55) | 44 (42–57) | 0.31 | |
| Race | White, n | 8 | 10 | 1.00 |
| Asian, n | 6 | 7 | ||
| FEV1 | Volume, L | 1.44 (0.96–1.68) | 1.18 (1.05–1.46) | 0.32 |
| Percentage of predicted value | 52 (35–60) | 44 (42–50) | 0.62 | |
| FVC | Volume, L | 3.19 (2.20–3.54) | 2.53 (2.03–2.85) | 0.15 |
| Percentage of predicted value | 84 (77–99) | 75 (66–82) | 0.15 | |
| FEV1/ FVC |
0.44 (0.38–0.58) | 0.48 (0.41–0.54) | 0.65 | |
| TLC | Volume, L | 5.68 (4.75–6.48) | 5.15 (4.59–5.57) | 0.13 |
| Percentage of predicted value | 114 (104–130) | 102 (97–131) | 0.19 | |
| FRC, n = 30 | Volume, L | 3.33 (2.43–3.60) | 2.98 (2.27–3.17) | 0.22 |
| Percentage of predicted value | 117 (112–129) | 109 (101–117) | 0.18 | |
| RV | Volume, L | 2.45 (1.84–2.86) | 2.36 (2.13–2.79) | 0.86 |
| Percentage of predicted value | 149 (113–209) | 149 (113–188) | 0.92 | |
| DlCO, n = 30 | ml/min/mm Hg | 12.0 (6.96–14.0) | 8.93 (8.30–11.95) | 0.65 |
| Percentage of predicted value | 46.7 (33.0–62.6) | 43.2 (37.6–49.5) | 0.65 | |
| Expiratory cyst volume, % | 13.89 | 16.35 | 0.45 | |
Definition of abbreviations: DlCO = diffusing capacity of carbon monoxide; RV = residual volume; TLC = total lung capacity.
The median values for the age and pulmonary function test variable values are presented. The lower and upper quartiles are represented in parentheses.