Table 2.
The Markov-chain cyst-transition (from TLC to RV) matrix analysis
| Cyst Volume Definitions | Cyst Size Transition (from TLC to RV) | Number of Cysts Transitioning in Size during Expiration (from TLC to RV) |
P Values for Placebo vs. Sirolimus | |||
|---|---|---|---|---|---|---|
| Placebo (n = 14) |
Sirolimus (n = 17) |
|||||
| Baseline, % (SD) | 12 Mo, % (SD) | Baseline, % (SD) | 12 Mo, % (SD) | |||
| Threshold 1 (small, <50 ml; medium, <200 ml and >50 ml; large, >200 ml) | Medium to small | 32 (19) | 24 (17) | 18 (22) | 18 (20) | 0.02 |
| Large to medium | 0 (0) | 0 (0) | 0 (2) | 0 (1) | ns | |
| Large to small | 54 (27) | 46 (27) | 30 (31) | 34 (29) | 0.02 | |
| Threshold 2 (small, <20 ml; medium, <100 ml and >20 ml; large, >100 ml) | Medium to small | 13 (14) | 8 (10) | 7 (10) | 5 (8) | ns |
| Large to medium | 1 (3) | 2 (4) | 0 (1) | 1 (2) | ns | |
| Large to small | 46 (24) | 37 (22) | 25 (28) | 27 (25) | 0.005 | |
| Threshold 3 (small, <20 mm3; medium, <50 ml and >20 ml; large, >50 ml) | Medium to small | 7 (11) | 4 (6) | 3 (6) | 2 (5) | ns |
| Large to medium | 2 (3) | 3 (4) | 2 (3) | 3 (3) | ns | |
| Large to small | 36 (20) | 28 (18) | 20 (23) | 20 (21) | 0.006 | |
Definition of abbreviations: ns = not significant; RV = residual volume; SD = standard deviation; TLC = total lung capacity.
Data are presented as the percentage of LAM cysts transitioning in volume from TLC to RV at baseline and 12 months. Volume categories were arbitrarily defined on the basis of thresholds listed in the left column. The differences from baseline to 12 months in the numbers of cysts transitioning between volume categories during expiration were then compared between the placebo and sirolimus groups.