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. 2016 Jun 15;36(24):6471–6487. doi: 10.1523/JNEUROSCI.0299-16.2016

Figure 5.

Figure 5.

Progressive motor function impairment is caused at later ages in the PlpCreERT;Mek/Mek mice, but not in the PlpCreERT;Mek/+ mice. Rotarod (A) and wire-hanging (B) tests performed at 2–3, 6, and 8 MPI show that PlpCreERT;Mek/Mek, but not PlpCreERT;Mek/+, mice display a progressive reduction in the latency to fall. C, Imprints of hindpaws taken at 6 MPI show that, whereas the control and PlpCreERT;Mek/+ mice have a normal gait, the PlpCreERT;Mek/Mek mice show a dragging motion of their hind feet. Error bars indicate SEM. **p < 0.01. n = 4–9.