Table 2.

Anti-breast cancer and antiepileptic activities of the compounds 6a–q

Compound	GI50 (μM)a	MES		PTZb
		0.5 hours	4 hours	0.5 hours	4 hours
6a	37.1	–	–	300	300
6b	>100	30	30	100	100
6c	76.4	30	30	100	300
6d	57.3	–	–	30	30
6e	46.9	100	300	30	30
6f	62.7	–	–	300	300
6g	>100	30	30	100	100
6h	45.1	300	300	100	100
6i	34.7	–	–	30	100
6j	>100	100	100	100	300
6k	38.2	100	300	100	100
6l	45.9	–	–	30	30
6m	>100	100	100	100	100
6n	76.6	–	–	100	100
6o	64.1	300	300	300	300
6p	77.9	100	100	100	100
6q	>100	100	100	100	100
Adriamycin	<0.1
Phenytoin		30	30
Sodium valproate				200	200

Notes:

^aGI₅₀ is the concentration of drug causing 50% inhibition of cell growth.

^bDoses of 30 mg/kg, 100 mg/kg, and 300 mg/kg were administered. The figure in the table indicates the minimum dose required for bioactivity in half or more of the mice examined at 0.5 hours and 4 hours. Dash indicates the absence of anticonvulsant activity and neurotoxicity at the maximum dose administered (300 mg/kg).

Abbreviations: MES, maximal electroshock seizure; PTZ, pentylenetetrazole.