Table 4. Cox Regression analysis for the combined endpoint as dependent variable and clinical factors as covariates in the overall cohort of cardiovascular patients.

Variable	HR rs2839693 (95% CI) **	p	q-value
CVRF
Hypertension	0.82 (0.45/1.50)	0.527	0.184
Hyperlipoproteinaemia	0.78 (0.50/1.22)	0.278	0.166
Smoker	0.77 (0.47/1.28)	0.320	0.176
Diabetes mellitus type II	1.18 (0.76/1.84)	0.459	0.184
Medication
ASA	2.08 (1.24/3.49)	0.006	0.017
Clopidogrel	1.07 (0.59/1.96)	0.820	0.212
ACE inhibitors	0.69 (0.44/1.10)	0.119	0.1
Beta blockers	1.17 (0.70/1.93)	0.552	0.184
Statins	0.85 (0.53/1.39)	0.524	0.184
Clinical factors
Age	1.06 (1.03/1.08)	<0.001	0.017
Gender	0.98 (0.61/1.57)	0.975	0.224
LVEF% class*	1.52 (1.24/1.87)	<0.001	0.017
Groups
SDF1 SNP	0.51 (0.30/0.88)	0.015	0.021

*numerically coded as 0 (normal), 1 (mild), 2 (moderate), and 3 (severe impairment)

**the SNP rs2839693 is highly correlated with rs266089 (LD = 98, r² = 94), as described in the Supporting Information.