Table 5. SDF1 haplotypes and their effects on the combined endpoint in uni- and multivariate Cox regression.

	SDF1 variants*							Univariate analysis		Multivariate analysis†
Haplotype‡	1	2	3	4	5	6	Frequency (%)	HR (95% CI)	p (Wald test)	HR (95% CI)	p (Wald test)
ReferenceH-01							47.3	-	-	-	-
H-02							18.7	0.98 (0.62/1.53)	0.922	0.76 (0.46/1.25)	0.285
H-03							15	1.09 (0.71/1.66)	0.687	1.00 (0.63/1.59)	0.996
H-04							13.8	0.59 (0.35/1.00)	0.052	0.47 (0.27/0.84)	0.0107

1 rs1065297, 2 rs1801157, 3 rs266089, 4 rs266087, 5 rs266085, 6 rs2839693

* variants are ordered according to chromosomal position (GRCh38); light grey/dark grey = carriers of major/minor allele

^† with covariates as listed in Table 4

^‡ listed are only haplotypes with frequencies ≥ 5%