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. 2016 Sep 8;11(9):e0162606. doi: 10.1371/journal.pone.0162606

Fig 1. Immunohistochemical staining of steroidogenic acute regulatory protein (StAR) in cortisol-producing ACAs with different genotypes.

Fig 1

(A) Wild-type adenoma presenting with low StAR expression (H-score = 100); adenomas with mutations in (B) PRKAR1A (H-score = 200), (C) GNAS (H-score = 200), and (D) PRKACA presenting with high StAR expression (H-score = 200) (scale bar, 50 μm). PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha; GNAS, guanine nucleotide binding protein, alpha stimulating; PRKACA, protein kinase cyclic adenosine monophosphate (cAMP)-activated catalytic subunit alpha.