Figure 1.

RU486 in combination with tubGS produces dose-dependent lethality. (A) Number of tubGS progeny eclosing at different doses of RU486 present throughout development, mean ± SD per vial, in OregonR background. Note that at 100 μM, no flies eclosed. * and # indicate significant differences from the next higher concentration tested in pairwise comparisons (Student’s t-test, P < 0.01 and 0.05, respectively). (B) Proportion (% of pupae formed) of tubGS progeny at different doses of RU486 present throughout development; combined data from sets of four vials at a given concentration, set up in parallel, in w¹¹¹⁸ background. n = 205 (at 5 M), 193 (at 7.5 μM), 210 (at 10 μM), and 146 (at 12.5 μM). tubGS plus RU486 produced comparable amounts of pupal lethality also in the CantonS background. SD, standard deviation; tubGS; α-tubulin-GeneSwitch.