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. 2016 Jul 21;6(9):2893–2907. doi: 10.1534/g3.116.032490

Table 2. Genes whose disruption confers sensitivity to 100 ng/ml caspofungin in YPD medium.

C gla Locus Tag S. cerevisiae Homolog Gene Name Description of Gene Product (Engel et al. 2016)
PKC/cell wall integrity pathway
CAGL0I06512g YER155c BEM2 RhoGAP involved in the control of cytoskeleton organization
CAGL0C05599g YDL240w LRG1 Putative GAP appears to specifically regulate β-1,3 glucan synthesis
CAGL0J03828g YPL140C MKK1 MAPKK involved in control of cell integrity
CAGL0G09559g YOR188w MSB1 Unknown function; may be involved in positive regulation of β-1,3 glucan synthesis and the Pkc1-MAPK pathway
CAGL0G01320g YNL053W MSG5 Dual-specificity protein phosphatase/ regulates Slt2
CAGL0E04620g YDR055w PST1 Cell wall protein that contains a putative GPI-attachment site
CAGL0J00539g YHR030c SLT2 Serine/threonine MAP kinase; regulates cell wall integrity
CAGL0A04565g YER111c SWI4 DNA binding component of the SBF complex
Cytoskeleton and vesicular transport
CAGL0J04312g YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases
CAGL0E05302g YOR329c SCD5 Protein required for normal actin organization and endocytosis
CAGL0G05786g YDL212w SHR3 Endoplasmic reticulum packaging chaperone
CAGL0K05291g YPR032W SRO7 Effector of Rab GTP-binding protein Sec4
High affinity Ca2+ influx (HACS)
CAGL0B02211g YGR217W CCH1 Voltage-gated high-affinity Ca2+ channel
CAGL0M00748g YLR443W ECM7 Role in Ca2+ uptake
CAGL0M03597g YNL291C MID1 Ca2+-permeable cation channel required for Ca2+ influx
Mannan synthesis
CAGL0K11231g YDR245w MNN10 Subunit of a Golgi mannosyltransferase complex
CAGL0M02871g YJL186w MNN5 α-1,2-mannosyltransferase
CAGL0J08734g YAL023c PMT2 Protein O-mannosyltransferase
CAGL0B02321g YML115C VAN1 Component of the mannan polymerase I
Cell signaling/response to stress
CAGL0L11110g YLR433c CNA1 Calcineurin A; regulates Crz1
CAGL0K01507g YDL035c GPR1 Plasma membrane GPCR; nutritional state sensor
Vacuole
CAGL0F06347g YMR054W STV1 Subunit a of the vacuolar-ATPase V0 domain
Transcriptional/translational regulation
CAGL0M06831g YNL027w CRZ1 TF, activates transcription of stress response genes
CAGL0J10120g YNL068c FKH2 Forkhead family transcription factor
CAGL0M13431g YHR187w IKI1 Subunit of hexameric RecA-like ATPase Elp456 elongator subcomplex
CAGL0C04477g YDL005c MED2 Subunit of the RNA polymerase II mediator complex
CAGL0M07029g YCR077C PAT1 Deadenylation-dependent mRNA-decapping factor
CAGL0J03322g YER082C UTP7 Nucleolar protein/processing of pre-18S rRNA
CAGL0H04367g YML076C WAR1 Homodimeric Zn2Cys6 zinc finger transcription factor
DNA replication/repair/cell cycle regulation
CAGL0D06028g YJR053w BFA1 Component of the GTPase-activating Bfa1-Bub2 complex
CAGL0I02222g YHR164C DNA2 Tripartite DNA replication factor
CAGL0K09438g YOR144c ELG1 Subunit of a complex important for DNA replication/genome integrity
CAGL0A03300g YGL192w IME4 mRNA N6-adenosine methyltransferase required for entry into meiosis
CAGL0D05786g YLL002w RTT109 Histone acetyltransferase
CAGL0A03432g YLR032w RAD5 DNA helicase
CAGL0E02475g YOL004W SIN3 Component of the Sin3-Rpd3 histone deacetylase complex
Proteosome
CAGL0G09493g YOR191w ULS1 Protein involved in proteolytic control of sumoylated substrates
Miscellaneous and unknown functions
CAGL0E03355g YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family
CAGL0J08910g YLR213c CRR1 Putative glycoside hydrolase of the spore wall envelope
CAGL0M05511g YBR207w FTH1 Putative high affinity iron transporter
CAGL0E03311g YGR163w GTR2 Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle
CAGL0I07447g YOL103w ITR2 Myo-inositol transporter
CAGL0J07436g YNL231c PDR16 PITP controlled by the multiple drug resistance regulator Pdr1
CAGL0H04213g YML081W TDA1 Protein kinase with unknown role; localizes to cytosol and nucleus
CAGL0J09966g YNL064c YDJ1 Type I HSP40 cochaperone
CAGL0M08250g YKL175w ZRT3 Vacuolar membrane zinc transporter
CAGL0L05060g YKL075c Unknown function; localizes to cytosol
CAGL0K03377g YMR102C Unknown function; paralog of Dgr2