. 2016 Sep 8;11(9):e0162444. doi: 10.1371/journal.pone.0162444

Table 2. The GRAIL 6MWTs.

		GRAIL 6MWT (1)		GRAIL 6MWT (2)
		Patients	Healthy elderly	Patients	Healthy elderly
6MWD, m		449.7 ± 89.3	639.9 ± 77.1^#	476.4 ± 86.8 ^a ^*	689.5 ± 62.2^* ^#
Walking speed, km/h		4.5 ± 0.9	6.4 ± 0.8^#	4.8 ± 0.9 ^a ^*	6.9 ± 0.7^*^#
Oxygen saturation, %	Pre	94.9 ± 1.8 ^a ^b	97.2 ± 1.2 ^a ^#	95.5 ± 1.6 ^a ^*	97.2 ± 1.0 ^a ^#
Oxygen saturation, %	Post	93.4 ± 4.4 ^a	97.4 ± 0.9 ^a ^#	93.2 ± 4.8 ^a	97.2 ± 1.3 ^a ^#
Δ Post-Pre Oxygen saturation, %		-1.5 ± 3.9 ^a ^b ^ǂ	0.2 ± 1.0 ^a ^ǂ ^#	-2.3 ± 4.3 ^ǂ ^*	0.0 ± 1.0 ^a ^#
Heart rate, bpm	Pre	82.4 ± 14.9 ^b	65.0 ± 11.1^#	83.7 ± 14.7	68.0 ± 12.2^*^#
Heart rate, bpm	Post	100.9 ± 16.4	89.3 ± 21.6^#	102.5 ± 17.9	99.5 ± 21.1 ^a ^*
Δ Post-Pre Heart rate, bpm		18.7 ± 11.0 ^a ^b ^ǂ	24.3 ± 15.5^ǂ	18.8 ± 10.0 ^a ^ǂ	31.5 ± 14.2 ^ǂ ^* ^#
Borg dyspnoea, points	Pre	1.3 ± 1.1 ^a	0.2 ± 0.4 ^a ^#	1.4 ± 1.2 ^a	0.3 ± 0.5 ^a ^#
Borg dyspnoea, points	Post	4.5 ± 2.0 ^a	1.1 ± 1.0 ^a ^#	4.6 ± 2.3 ^a	1.2 ± 1.1 ^a ^#
Δ Post-Pre Borg dyspnoea, points		3.2 ± 2.0 ^ǂ	0.9 ± 1.0 ^a ^ǂ ^#	3.2 ± 2.2 ^ǂ	0.9 ± 0.9 ^a ^ǂ ^#
Borg fatigue, points	Pre	1.5 ± 1.3 ^a	0.3 ± 0.6 ^a ^#	1.5 ± 1.3 ^a	0.3 ± 0.6 ^a ^#
Borg fatigue, points	post	4.3 ± 2.4 ^a	1.3 ± 1.2 ^a ^#	4.6 ± 2.3 ^a	1.3 ± 1.1 ^a ^#
Δ Post-Pre Borg fatigue, points		2.8 ± 2.3 ^ǂ	1.0 ± 1.1 ^a ^ǂ ^#	3.1 ± 2.1 ^ǂ	1.0 ± 1.1 ^a ^ǂ ^#

Data are presented as n or mean ± standard deviation. Bpm: beats per minute.

^ǂ: significant difference between pre and post symptoms per trial.

*: significant difference between the first and second GRAIL 6MWT within each group.

^#: significant difference between patients and healthy elderly.

^a: nonparametric test have been used.

^b: missing value in patients, N = 60.