Figure 7.
Evaluating the impact of eutrophic remodeling on vascular measurements. Left: The solid line shows the measured relation between ID and OD for LTN subjects (r2 = 0.99). Dashed curves show how individual vessels would be affected with increased eutrophic remodeling. Thus, if we measure a vessel with OD and ID as represented by point A, it would presumably, prior to hypertensive remodeling, have been located at point B. This implies that the vessel changed its inner diameter as shown by the double headed arrow. Right. The computed normalized change in resistance based on a fourth power relation between lumen size and resistance. Note that the largest resistance changes occurred for our measured small vessels, however their total length is relatively small, which supports the idea that the largest changes in total systemic resistance do not arise from the smallest vessels.