Figure 5.

Effect of opsin deletion and P23H mutant knock-in on retinal generation of superoxide in mice at 2, 4, and 10 months of age (0, 2, or 8 months of diabetes, respectively). Data are expressed relative to age-matched nondiabetic WT (C57Bl/6J) mice. Data used to calculate superoxide values by the retinas of opsin-deficient mice nondiabetic and diabetic for 2 months (4 months of age) were reported previously,²⁸ but are regraphed here to show the results relative to age-matched nondiabetic C57Bl/6J mice. Nondiabetic mice, solid lines with squares; diabetic mice, dashed lines with circles. n = 3 to 10 in all groups. *P < 0.05 or ***P < 0.001 compared to N C57Bl/6J controls; †P < 0.05 or †††P < 0.001 compared to D C57Bl/6J controls. N, nondiabetic; D, diabetic.