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. 2016 Sep 8;14(9):e2000197. doi: 10.1371/journal.pbio.2000197

Table 1. The incidence of atrial septal defects (ASD) as a function of Nipbl genotype in the heart.

Conditional haploinsufficiency experiments (Flox/+ x Cre)
Nipbl genotype in cardiomyocyte (cTnt) lineage Nipbl genotype in Sox17 lineage Frequent ASDs?
+/+ +/+ no
+/- +/+ yes
+/+ +/- yes
Conditional rescue experiments (FLEX/+ x Cre)
Nipbl genotype in cardiomyocyte (cTnt) lineage Nipbl genotype in Sox17 lineage Frequent ASDs?
+/+ +/+ no
+/- +/+ no
+/+ +/- no