Table 1. The incidence of atrial septal defects (ASD) as a function of Nipbl genotype in the heart.
Conditional haploinsufficiency experiments (Flox/+ x Cre) | ||
Nipbl genotype in cardiomyocyte (cTnt) lineage | Nipbl genotype in Sox17 lineage | Frequent ASDs? |
+/+ | +/+ | no |
+/- | +/+ | yes |
+/+ | +/- | yes |
Conditional rescue experiments (FLEX/+ x Cre) | ||
Nipbl genotype in cardiomyocyte (cTnt) lineage | Nipbl genotype in Sox17 lineage | Frequent ASDs? |
+/+ | +/+ | no |
+/- | +/+ | no |
+/+ | +/- | no |