Table 2.
Studies on low dose RT for FL.
| Authors | Pts (n) | Histology | Stage | Dose/fx | Response rate | Survival | Toxicity |
|---|---|---|---|---|---|---|---|
| Girinsky et al, 200138 | 48 | Low grade | I 15% II 23% III 27% IV 31% |
4 Gy/2 fx | CR 57% PR 24% |
Median duration of response: 24 months 2yr FFLP 56% | No events |
| Johannsson et al, 200239 | 15 | Indolent NHL | Advanced | 4 Gy/2 fx | CR 74% PR 13% |
Median duration of response: 22 months | No events |
| Haas et al, 200340 | 109 | Indolent NHL (FL=98), | Advanced (52%bulky) | 4 Gy/2 fx | CR 61% PR 31% SD 6% PD 2% |
Median duration of response: 42 months Median TTLP: 25 months PFS1yr 50% PFS2yrs 33% PFS3yrs 25% PFS5yrs 10% |
No events |
| Murthy et al, 200841 | 29 | Indolent NHL | Advanced | 4 Gy/2 fx | ORR 86% | NR | No events > G2 |
| Russo et al, 201242 | 127 | Indolent NHL (including CLL) | I (16%) II (10%) III (31%) IV 43%) |
4 Gy/2 fx | CR 57% PR 25% |
TTP 13.6 months | No events |
Abbreviations: NHL (non-Hodgkin’s lymphoma); FFLP (freedom from local progression); TTLP (time to local progression); PFS (progression free survival); CLL (chronic lymphatic leukemia); CR (complete response); PR (partial response); SD (stable disease); PD (progressive disease), ORR (overall response rate); NR (not reported).