Table 1.
Comparison between studied groups as regard main clinical presentations and laboratory data at the time of diagnosis.
| Clinical presentations | Group I (No=40) | Group II (No=40) | X2 | P-value | |
|---|---|---|---|---|---|
|
| |||||
| Age (years) | |||||
| Range | 4–13 | 4–12 | 0.259 | 0.614 | |
| Mean + SD | 6.85 ± 2.89 | 7.30 ± 2.69 | |||
|
| |||||
| Sex | |||||
| Male | 24 (60% | 26 (65%) | 0.107 | 0.500 | |
| Female | 16 (40%)) | 14 (35%) | |||
|
| |||||
| Fever | 22 (55%) | 20 (50%) | 0.100 | 0.500 | |
|
| |||||
| Pallor | 31 (77.5%) | 32 (80%) | 0.025 | 0.653 | |
|
| |||||
| Purpura | 28 (70%) | 30 (75%) | 2.667 | 0.095 | |
|
| |||||
| CNS infiltration | 2 (5%) | 2 (5%) | 0.023 | 0.756 | |
|
| |||||
| Bone ache | 18 (45%) | 16 (40%) | 0.114 | 0.500 | |
|
| |||||
| Hepatomegaly | 38 (95%) | 34(85%) | 3.137 | 0.091 | |
|
| |||||
| Splenomegaly | 40 (100%) | 36 (90%) | 5.714 | 0.054 | |
|
| |||||
| Lymphadenopathy | 28 (70%) | 26(65%) | 1.758 | 0.160 | |
|
| |||||
| Immunophenotyping | |||||
| Early pre-B-ALL | 30 | 28 | X2 3.034 |
0.219 | |
| Pre-B-ALL | 6 | 10 | |||
| T-ALL | 4 | 2 | |||
|
| |||||
| Hb (g/dl) | Range | 5.9 – 11.5 | 3 – 12.9 | 3.105 | 0.086 |
|
| |||||
| Mean ± SD | 7.92 ±1.86 | 6.69 ± 2.49 | |||
|
| |||||
| MCV(fL) | Range | 70 – 99 | 70 – 99 | 1.249 | 0.271 |
|
| |||||
| Mean ± SD | 81.81 ± 7.57 | 84.55 ± 7.96 | |||
|
| |||||
| MCH (pg) | Range | 26 – 31 | 28 – 33 | 1.136 | 0.293 |
|
| |||||
| Mean ± SD | 29.41 ± 1.34 | 29.9 ± 1.59 | |||
|
| |||||
| MCHC (%) | Range | 29 – 34.5 | 31 – 35 | 1.647 | 0.207 |
|
| |||||
| Mean ± SD | 31.9 ± 1.66 | 32.5 ± 1.28 | |||
|
| |||||
| WBCs (103/mm3) | Range | 1.9 – 121 | 2.7 – 130 | 1.997 | 0.166 |
|
| |||||
| Mean ± SD | 28.61 ± 86.63 | 32.15 ± 90.07 | |||
|
| |||||
| Platelets (103/mm3) | Range | 20 – 293 | 10 – 191 | 1.426 | 0.240 |
|
| |||||
| Mean ± SD | 83.7± 63.92 | 72.3 ± 48.33 | |||
|
| |||||
| Peripheral blood Blast cells % | Range | 0 – 86 | 0 – 90 | 4.124 | 0.09 |
|
| |||||
| Mean ± SD | 37.25 ± 24.85 | 40.8 ±27.82 | |||
CNS: Central Nervous System. Hb: Hemoglobin, WBCS: White blood cells, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration.