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. Author manuscript; available in PMC: 2017 Sep 2.
Published in final edited form as: Circ Res. 2016 Jul 18;119(6):e91–e103. doi: 10.1161/CIRCRESAHA.116.308955

Figure 7.

Figure 7

(a) Atherosclerotic lesion area and (b) necrotic core area at aortic roots in Ldlr−/− recipients fed with WTD for 10 and 12 weeks respectively (n=14–16). (c) Representative images of H&E staining of aortic root atherosclerosis lesions of WT and Lnk −/− BM recipient mice. (d) Accumulation of fluorescence bead labeled monocytes in atherosclerotic lesions. Atherosclerotic lesional macrophage (e) and neutrophil (f) staining from mice on WTD for 10 weeks. N=14–16. (g) Schematic summary. Hypercholesterolemia enriches platelet membrane, including lipid rafts, with cholesterol and inhibits LYN Kinase activity. Together with increased TPO/MPL signaling due to LNK deficiency, hypercholesterolemia and LNK deficiency act convergently to activate AKT and platelets in a 2 hit model.