Skip to main content
. Author manuscript; available in PMC: 2016 Dec 8.
Published in final edited form as: Sci Transl Med. 2016 Jun 8;8(342):342ra78. doi: 10.1126/scitranslmed.aaf3634

Figure 2.

Figure 2

Evidence of impaired mitochondrial protein import in human dopaminergic substantia nigra neurons in Parkinson’s disease. (A) In TH+ dopamine neurons from PD cases, there was an intense α-synuclein:TOM20 PL signal and a marked loss of Ndufs3 immunoreactivity. In PD cases, remaining Ndufs3 staining was rather diffuse instead of punctate. (B) Quantification of the α-synuclein:TOM20 PL signal in control vs. PD dopamine neurons. (C) Quantification of Ndufs3 immunoreactivity in control vs. PD dopamine neurons. The Ndufs3 signal was normalized to the TH signal, which tends to minimize the apparent differences. ***p<0.0001; *p <0.05; 2-tailed unpaired t-test with Welch’s correction for unequal variances.