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. 2016 Jun 15;291(33):17369–17381. doi: 10.1074/jbc.M115.708883

FIGURE 2.

FIGURE 2.

Neuritin-induced Kv4.2 expression and IA densities require NFATc4. A, effect of neuritin on Kv4.2 protein expression in CGNs isolated from wild type mice (C57BL/6), Nfatc2−/−, Nfatc4−/−, and the combined Nfatc2−/− and Nfatc4−/− DKO mice measured by Western blotting. B, induction of IA densities recording from C57BL/6 and Nfatc4−/− mouse CGNs after neuritin stimulation. C, induction of Kv4.2 mRNA level measured by quantitative RT-PCR from C57BL/6 and Nfatc4−/− mouse CGNs after neuritin stimulation. The data were obtained from three independent experiments. D, representative sample showing Western blotting-detected expression of NFATc4 protein in mouse cerebellum and PFC from C57BL/6 and Nfatc4−/− mice. *, p < 0.05; **, p < 0.01; and ***, p < 0.001 for two groups connected with a straight line by one-way ANOVA followed by Fisher's post hoc test.