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. 2016 Jun 20;291(33):17394–17404. doi: 10.1074/jbc.M116.728949

FIGURE 4.

FIGURE 4.

XBP1s reduces lipogenic gene expression in livers of fructose-fed mice. C57Bl6/J mice were fed a fructose diet for 4 weeks (starting at 8 weeks of age) and then injected with adLacZ or adXBP1s (8*10E7 pfu/g) through the tail vein. A, relative hepatic mRNA levels of Xbp1s, Srebp1c, FasN, Acc1, Acc2, and Scd1 livers of adLacZ- and adXBP1s-injected mice on day 9 post-adenovirus injection. Gene expression was normalized using the 18s gene as a housekeeping gene. B and C, liver triglyceride content (B) and plasma triglyceride levels (C) were determined in 6 h-fasted mice on day 9 post-adenovirus injection. D, blood glucose levels as determined in 6 h-fasted mice on day 9 post-adenovirus injection. E and F, average daily food intake (E) and body weight (F) in 6 h-fasted mice on day 9 post-adenovirus injection. Error bars are represented as mean ± S.E.; p values were determined by Student's t test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.