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The cytoplasmic domains of Ptch1 are sufficient for oligomerization. A, GFP-tagged ML and HA-tagged C terminus constructs were co-transfected in HEK 293 cells. Immunoprecipitation of HAC-term co-immunoprecipitates GFPML. IB, immunoblot. B, co-expression of HA- and GFP-tagged C terminus constructs. α-HA immunoprecipitation pulls down the GFP-tagged variant of the ML domain. All blots are representative of at least two independent experiments.
