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Membrane binding properties of Lck, Lck-SH2, and mutants
| Proteins | Kda |
|---|---|
| nm | |
| Lck-SH2 WTb | 160 ± 15 |
| Lck-SH2 K182A/R184Ab | 430 ± 10 |
| Lck-SH2 A160Kb | 120 ± 10 |
| Lck FLc WT | 220 ± 80 |
| PLCδ-PH WT | 240 ± 60 |
| PLCδ-PH R56A/R60A | 480 ± 100 |
a Means ± S.D. were taken from triplicate equilibrium SPR measurements using PM mimetic vesicles (POPC/POPE/POPS/cholesterol/PI/PI45P2 = 12:35:22:22:8:1).
b These are EGFP fusion proteins.
c FL means full-length proteins.
