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. 2016 Jun 24;291(34):17861–17880. doi: 10.1074/jbc.M116.718536

FIGURE 1.

FIGURE 1.

Analysis of androgen-induced lncRNAs in prostate cancer and identification of SOCS2-AS1 as a lncRNA highly expressed in castration-resistant prostate cancer. A, flow diagram for the identification of SOCS2-AS1 as an AR-targeted lncRNA up-regulated in LTAD cells. Venn diagram representing overlap of lncRNAs induced by androgen (10 nm DHT) and repressed by 1 mm bicalutamide and 10 nm siAR treatment for 24 h in LNCaP and VCaP cell lines. B, qRT-PCR analysis of androgen-induced lncRNAs by qRT-PCR in LNCaP cells. C, qRT-PCR analysis of androgen-induced lncRNAs by qRT-PCR in VCaP cells. Cells were treated with 100 nm DHT or ethanol (Et) for 24 h. The expression level of each lncRNA was determined by qRT-PCR. n = 3. Expression levels are presented relative to the value of GAPDH as the reference gene. Values represent mean ± S.D.