Figure 1. TGF-β1-mediated LC differentiation.

A number of transcription factors and regulators form a network in TGF-β1-regulated LC development and maintenance, in which transcription factor PU.1 is a core factor. Red plus indicates a promoting role in LC differentiation, and green minus indicates an inhibitive role. Solid blue arrows indicate positive stimulatory functions that have been proven or suggested by previous reports. Dotted arrows indicate hypothesized relationships. Dark-grey lines indicate negative regulation. Peachblow rims indicate that the results derive from mouse experiments. Orange rims indicate that the results derive from human experiments. Purple rims indicate that the results derived from both mouse and human experiments.