Table 2. Hazard ratios (HR) of at-diagnosis body mass index and mortality* (N=3,408).
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| N | Event | Age, race, sex adjusted HR | 95% CI | MV-adjusted HR | 95% CI | |
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| All-cause mortality | ||||||
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| BMI (kg/m2)—WHO categories** | ||||||
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| <18.5 | 67 | 32 | 3.55 | (2.44, 5.17) | 3.01 | (1.88, 4.83) |
| 18.5-<25 | 1,050 | 198 | ref | ref | ||
| 25-<30 | 1,214 | 179 | 0.75 | (0.61, 0.92) | 0.81 | (0.64, 1.03) |
| 30-<35 | 671 | 119 | 0.94 | (0.74, 1.19) | 1.03 | (0.77, 1.38) |
| 35+ | 406 | 89 | 1.36 | (1.06, 1.76) | 1.63 | (1.13, 2.33) |
| BMI (kg/m2)—expanded categories | ||||||
| <18.5 | 67 | 32 | 3.06 | (2.07, 4.53) | 2.65 | (1.63, 4.31) |
| 18.5-<23 | 553 | 118 | Ref | ref | ||
| 23-<25 | 497 | 80 | 0.71 | (0.54, 0.95) | 0.77 | (0.56, 1.06) |
| 25-<28 | 787 | 125 | 0.70 | (0.54, 0.91) | 0.75 | (0.55, 1.04) |
| 28-<30 | 427 | 54 | 0.54 | (0.39, 0.74) | 0.52 | (0.35, 0.77) |
| 30-<35 | 671 | 119 | 0.80 | (0.62, 1.04) | 0.81 | (0.57, 1.15) |
| 35+ | 406 | 89 | 1.17 | (0.88, 1.55) | 1.33 | (0.89, 1.98) |
| CRC-specific mortality | ||||||
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| BMI (kg/m2)—WHO categories | ||||||
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| <18.5 | 67 | 20 | 3.29 | (2.05, 5.28) | 3.35 | (1.92, 5.87) |
| 18.5-<25 | 1,050 | 130 | ref | Ref | ||
| 25-<30 | 1,214 | 116 | 0.74 | (0.57, 0.95) | 0.77 | (0.57, 1.03) |
| 30-<35 | 671 | 92 | 1.07 | (0.81, 1.40) | 1.06 | (0.75, 1.50) |
| 35+ | 406 | 53 | 1.14 | (0.82, 1.58) | 1.47 | (0.96, 2.27) |
| BMI (kg/m2)—expanded categories | ||||||
| <18.5 | 67 | 20 | 3.02 | (1.84, 4.96) | 3.18 | (1.78, 5.69) |
| 18.5-<23 | 553 | 73 | ref | Ref | ||
| 23-<25 | 497 | 57 | 0.83 | (0.58, 1.17) | 0.89 | (0.60, 1.31) |
| 25-<28 | 787 | 84 | 0.76 | (0.55, 1.05) | 0.81 | (0.55, 1.19) |
| 28-<30 | 427 | 32 | 0.51 | (0.34, 0.78) | 0.45 | (0.28, 0.74) |
| 30-<35 | 671 | 92 | 0.97 | (0.71, 1.33) | 0.88 | (0.58, 1.32) |
| 35+ | 406 | 53 | 1.04 | (0.73, 1.49) | 1.12 | (0.61, 2.06) |
Age-adjusted HR adjusted for age (continuous), sex, and race (White (ref), Black, Hispanic, Asian/Pacific Islander, Other). MV-adjusted analysis adjusted additionally for stage (I (ref), II, III), grade (1, 2 (ref), 3, 4), chemotherapy (no (ref), yes), radiation (no (ref), yes), disease site (proximal (ref), distal, rectal), smoking (never (ref), past, current), physical activity (0, >0 to <120, 120+ minutes/wk), and pre-diagnosis BMI (<18.5, 18.5-<25 (ref), 25-<30, 30-<35, 35+ kg/m2).
Note: Adjustment for comorbidity attenuated the association of those with BMI 35+ for all-cause mortality to HR=1.27, 95% CI: 0.88-1.84 and for other cause mortality in analyses (data not shown). Adjustment for comorbidity had minimal influence on associations with colorectal cancer-specific mortality.