Table 4. Stratified analyses of weight and all-cause mortality (N=3,408)*.
| BMI at diagnosis (kg/m2) | ||||||||
|---|---|---|---|---|---|---|---|---|
| <18.5 | 18.5-<23 | 23-<25 | 25-<28 | 28-<30 | 30-<35 | ≥35 | p** | |
| Site | ||||||||
| Proximal, N | 36 | 264 | 223 | 333 | 191 | 288 | 191 | 0.005 |
| Events | 22 | 57 | 42 | 61 | 30 | 56 | 51 | |
| HR | 4.82 | 1.00 | 1.02 | 1.02 | 0.77 | 1.07 | 1.76 | |
| 95% CI | (2.57, 9.02) | (0.65, 1.61) | (0.64, 1.61) | (0.44, 1.33) | (0.64, 1.76) | (0.99, 3.13) | ||
| Distal, N | 11 | 132 | 124 | 205 | 125 | 192 | 120 | |
| Events | 2 | 28 | 13 | 21 | 11 | 35 | 16 | |
| HR | 0.86 | 1.00 | 0.40 | 0.38 | 0.32 | 0.86 | 0.49 | |
| 95% CI | (0.19, 3.76) | (0.19, 0.85) | (0.19, 0.79) | (0.13, 0.75) | (0.41, 1.83) | (0.20, 1.24) | ||
| Rectal, N | 20 | 157 | 150 | 249 | 111 | 191 | 95 | |
| Events | 8 | 33 | 25 | 43 | 13 | 28 | 22 | |
| HR | 1.73 | 1.00 | 0.75 | 0.65 | 0.37 | 0.47 | 1.39 | |
| 95% CI | (0.61, 4.86) | (0.42, 1.35) | (0.36, 1.18) | (0.16, 0.82) | (0.24, 0.93) | (0.67, 2.91) | ||
|
| ||||||||
| Stage | ||||||||
| I, N | 18 | 137 | 161 | 232 | 140 | 210 | 128 | 0.58 |
| Events | 5 | 18 | 13 | 19 | 9 | 13 | 10 | |
| HR | 4.04 | 1.00 | 0.57 | 0.48 | 0.39 | 0.56 | 1.25 | |
| 95% CI | (1.12, 14.6) | (0.24, 1.34) | (0.20, 1.18) | (0.14, 1.10) | (0.20, 1.54) | (0.39, 4.00) | ||
| II, N | 25 | 192 | 160 | 277 | 127 | 183 | 117 | |
| Events | 15 | 27 | 21 | 42 | 17 | 26 | 27 | |
| HR | 2.81 | 1.00 | 0.85 | 1.00 | 0.95 | 1.41 | 2.24 | |
| 95% CI | (1.31, 6.04) | (0.45, 1.63) | (0.53, 1.90) | (0.45, 2.01) | (0.68, 2.92) | (1.02, 4.93) | ||
| III, N | 24 | 224 | 176 | 278 | 160 | 278 | 161 | |
| Events | 12 | 73 | 46 | 64 | 28 | 80 | 52 | |
| HR | 1.87 | 1.00 | 0.76 | 0.69 | 0.37 | 0.66 | 1.01 | |
| 95% CI | (0.81, 4.31) | (0.50, 1.15) | (0.45, 1.04) | (0.22, 0.62) | (0.43, 1.03) | (0.61, 1.68) | ||
Models adjusted for age (continuous), sex, and race (White (ref), Black, Hispanic, Asian/Pacific Islander, Other), stage (I (ref), II, III), grade (1, 2 (ref), 3, 4), chemotherapy (no (ref), yes), radiation (no (ref), yes), and disease site (proximal (ref), distal, rectal), smoking (never (ref), past, current), physical activity (0, >0 to <120, 120+ minutes/wk), and pre-diagnosis BMI (<18.5, 18.5-<23 (ref), 23-<25, 25-<28, 28-<30, 30-<35, 35+ kg/m2) though models were not adjusted for the stratification variable.
p-value, Likelihood Ratio χ2 test for interaction
There were no significant differences in analyses stratified by age (< vs. ≥65 years) (p-value, test for interaction=0.83), race (p=0.18), comorbidity status (p=0.64), chemotherapy (p=0.41) or radiotherapy (p=0.63).