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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Biol Psychiatry. 2016 Mar 8;80(11):878–887. doi: 10.1016/j.biopsych.2016.02.031

Figure 7.

Figure 7

NMU administered during initiation but not expression blocks sensitization. (a) Schematic of experimental timeline for the expression of cocaine sensitization. Cocaine or saline was injected (i.p.) twice per day for 5 days during pretreatment. Rats received no treatments for 7 days. On challenge day, rats received a bilateral microinjection of NMU (0.3 nmol per side) or vehicle directly into the NAcSh. Following the microinjection, all rats received cocaine and locomotor activity was measured. (b) Challenge day locomotor activity measured by total horizontal beam breaks immediately following cocaine injection (n = 7–8 per group). (c) Schematic of experimental timeline for initiation of cocaine sensitization. NMU or vehicle is administered throughout pretreatment and not on challenge day. (d) Challenge day locomotor activity (n = 7–10 per group). Bar graphs show mean ± s.e.m. * p < 0.05 and **p < 0.01 between groups.