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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Nat Struct Mol Biol. 2016 Aug 1;23(9):821–829. doi: 10.1038/nsmb.3272

Fig. 7. Hsc70 binding makes cages less compressible but more prone to catastrophic deformations.

Fig. 7

A: Collision pressure model analogizes cages and cages+Hsc70 to balloons inflated to low and high pressure, respectively. Internal pressure generated by Hsc70s makes cages less deformable, but more prone to catastrophic deformation (bursting) especially as probing force is increased. B: Percent of cages +/− Hsc70 exhibiting indicated mean compressions with 100 pN force (mean compression for each cage is determined from 9–12 measurements obtained from probing each cage on a 3×3 or 4×4 grid, depending on cage size). C: As in B, but using a 200 pN tip force. D: Percent of cages exhibiting indicated maximum compressions during probing. Average max compressions for cage populations with max compressions <30 nm or >30nM are given (statistics in supplemental table 3).