Table 1.

Clinical and pathological features in 26 ET cases without DBS vs. 13 ET cases with DBS

	non-DBS	DBS	p-value
N	26	13
Age at death (yrs)	86.08 ± 6.63	85.08 ± 6.36	0.6551
Disease duration (yrs)	44.88 ± 22.29	44.46 ± 25.68	0.9591
Gender			0.7252
Male	8 (30.8%)	5 (38.5%)
Female	18 (69.2%)	8 (61.5%)
TTS	24.04 ± 5.53	28.58 ± 6.43	0.0281
Voice tremor			0.0052
No	19 (73.1%)	3 (23.1%)
Yes	7 (26.9%)	10 (76.9%)
Brain weight (g)	1189.40 ± 171.76	1228.18 ± 122.49	0.4731
Postmortem interval (h)	181.71 ± 197.22	190.22 ± 136.14	0.8521
Braak AD stage			0.6572
0	2 (7.7%)	0 (0.0%)
I	7 (26.9%)	2 (15.4%)
II	8 (30.8%)	3 (11.5%)
III	5 (19.2%)	5 (19.2%)
IV	3 (11.5%)	2 (7.7%)
V	0 (0.0 %)	0 (0.0%)
VI	1 (3.8 %)	1 (3.8%)
CERAD plaque score			0.4262
0	12 (46.2%)	4 (30.8%)
A	5 (19.2%)	5 (38.5%)
B	4 (15.4%)	3 (23.1%)
C	5 (19.2%)	1 (7.7%)
%CFPC1	35.35 ± 10.85	42.07 ± 3.28	0.0071
Purkinje axonal torpedoes	14.31 ± 10.38 [median = 13.00 ]	24.92 ± 22.03 [median = 18.00]	0.1353
Purkinje cell count*	8.44 ± 1.58	8.69 ± 1.38	0.6201

Values represent mean ± standard deviation [median] or number (percentage).

%CFPC1: the percentage of climbing fiber-Purkinje cell synapses on Purkinje cell (PC) dendrites of < 1μm thickness. % CFPC1 was calculated by dividing the number of VGlut2 puncta on PC dendritic branchlets < 1μm in diameter by the total number of VGlut2 puncta on a given PC dendritic arbor.

Postmortem interval: hours between death and placement of brain in a cold room or upon ice.

AD = Alzheimer’s disease; CERAD = the Consortium to establish a Registry for Alzheimer’s disease; g = grams; h = hours; TTS = total tremor score; yrs: years

^*Mean number of Purkinje cells (PCs) per 100x microscopic field, among 15 sampled fields.

¹Independent sample t-test

²Chi-square test

³Mann-Whitney test