Table 2.
Differences in hemodynamic parameters between study days and between baseline and during infusions.
Parameters | Intact | Autonomic Blockade | p (saline-trimt) | ||
---|---|---|---|---|---|
| |||||
Baseline | Saline | Baseline | Trimethaphan | ||
SBP, mm Hg | 153 ± 5.0 | 153 ± 5.2 | 156 ± 5.3 | 111 ± 4.50.003 | 0.003 |
DBP, mm Hg | 88 ± 3.0 | 89 ± 3.2 | 90 ± 3.8 | 70 ± 2.80.003 | 0.003 |
HR, bpm | 65 ± 3.6 | 62 ± 2.4 | 65 ± 3.5 | 78 ± 2.60.003 | 0.008 |
CO, L/min | 6.2 ± 0.6 | 6.5 ± 0.6 | 6.6 ± 0.7 | 5.7 ± 0.4 | 0.779 |
SV, mL | 94 ± 5.7 | 97 ± 5.6 | 99 ± 7.3 | 77 ± 3.80.016 | 0.05 |
TPR, dyn×sec×cm−5 | 1571 ± 128 | 1503 ± 121 | 1567 ± 131 | 1255 ± 86.30.021 | 0.036 |
MAP | 110 ± 3.3 | 111 ± 3.5 | 112 ± 4.0 | 84 ± 3.10.003 | 0.003 |
FBF | 2.8 ± 0.3 | 3.2 ± 0.4 | 3.2 ± 0.4 | 5.4 ± 0.70.001 | 0.016 |
FVR | 49.7 ± 7.4 | 42.5 ± 6.7 | 44.8 ± 6.8 | 20.0 ± 3.20.003 | 0.004 |
FVC | 2.5 ± 0.3 | 2.9 ± 0.4 *0.041 | 2.6 ± 0.3 | 1.97 ± 0.80.003 | 0.004 |
Values are expressed as mean ± S.E.M. The “p (before-after)” column reflects differences between study days (intact vs. blocked) during the infusions (saline or trimethaphan)
p <0.05 for the comparison between baseline and infusion for each study day.
No significant differences were observed between study days at baseline.