Table 3.
Differences between study days
| Parameters | Intact | Autonomic Blockade | ||
|---|---|---|---|---|
|
| ||||
| ACh | SNP | ACh | SNP | |
| MAP, mm Hg | ||||
| Dose 1 | 109 ± 4.4 | 108 ± 4.8 | 81 ± 3.1 | 83 ± 3.4 |
| Dose 2 | 107 ± 4.1 | 108 ± 4.5 | 81 ± 3.6 | 78 ± 4.1 |
| Dose 3 | 108 ± 3.8 | 106 ± 4.2 | 78 ± 3.2 | 74 ± 3.4 |
| P dose | 0.922 | 0.253 | ||
| P drug | 0.819 | 0.532 | ||
| P drug×dose | 0.998 | 0.644 | ||
| FBF, ml/100 mL | ||||
| Dose 1 | 4.2 ± 0.6 | 4.1 ± 0.5 | 7.9 ± 1.0 | 6.9 ± 0.8 |
| Dose 2 | 6.0 ± 0.5 | 8.1 ± 0.4 | 10.7 ± 1.2 | 10.4 ± 1.3 |
| Dose 3 | 7.2 ± 0.5 | 10.2 ± 0.7 | 13.2 ± 1.3 | 11.8 ± 1.0 |
| P dose | 0.001 | 0.000086 | ||
| P drug | 0.000 | 0.318 | ||
| P drug×dose | 0.016 | 0.873 | ||
| FVR, (MAP/FBF) | ||||
| Dose 1 | 36.6 ± 7.4 | 33.7 ± 5.4 | 13.2 ± 1.9 | 13.8 ± 1.2 |
| Dose 2 | 19.4 ± 1.5 | 13.5 ± 1.2 | 9.2 ± 1.2 | 8.6 ± 0.6 |
| Dose 3 | 16.5 ± 1.6 | 10.9 ± 0.8 | 6.9 ± 0.8 | 7.0 ± 0.6 |
| P dose | 0.000 | 0.000 | ||
| P drug | 0.117 | 0.985 | ||
| P drug×dose | 0.959 | 0.872 | ||
| FVC, AU | ||||
| Dose 1 | 3.8 ± 0.7 | 3.6 ± 0.5 | 9.3 ± 1.4 | 7.8 ± 0.7 |
| Dose 2 | 5.6 ± 0.5 | 7.8 ± 0.5 | 13.1 ± 1.9 | 12.4 ± 1.0 |
| Dose 3 | 6.6 ± 0.7 | 9.7 ± 0.8 | 16.9 ± 2.3 | 15.6 ± 1.6 |
| P dose | 0.000 | 0.000 | ||
| P drug | 0.001 | 0.346 | ||
| P drug×dose | 0.029 | 0.971 | ||
Values are expressed as mean ± S.E.M. The “p dose” reflects the effects of the different doses for both drugs, the “p drug” reflects the effects of each drug, the “p drug×dose” reflects the combined effect of both drug and the different doses.