Table 2.
RR of gout by diuretic use, stratified by median genetic scores
| HPFS | NHS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| < median | ≥ median | P for interaction | < median | ≥ median | P for interaction | |||||
| Genetic score of 8 SNPs | ||||||||||
|
| ||||||||||
| Any diuretic use | No | Yes | No | Yes | No | Yes | No | Yes | ||
| No. of Cases | 229 | 38 | 404 | 56 | 73 | 53 | 120 | 108 | ||
| Person-Years | 37835 | 1673 | 37533 | 1836 | 78216 | 13386 | 79389 | 12936 | ||
| Age-adjusted | 1.00 | 4.57 (3.08, 6.76) | 1.00 | 3.10 (2.29, 4.20) | 0.25 | 1.00 | 3.89 (2.69, 5.62) | 1.00 | 4.81 (3.67, 6.31) | 0.22 |
| MV-adjusted | 1.00 | 2.20 (1.42, 3.42) | 1.00 | 1.69 (1.21, 2.37) | 0.27 | 1.00 | 1.97 (1.32, 2.93) | 1.00 | 2.33 (1.73, 3.13) | 0.21 |
| Thiazide diuretic use | No | Yes | No | Yes | No | Yes | No | Yes | ||
| No. of Cases | 237 | 30 | 414 | 46 | 88 | 38 | 146 | 82 | ||
| Person-Years | 38060 | 1448 | 37725 | 1644 | 79787 | 11815 | 80731 | 11594 | ||
| Age-adjusted | 1.00 | 3.91 (2.55, 5.99) | 1.00 | 2.86 (2.06, 3.98) | 0.33 | 1.00 | 2.77 (1.88, 4.10) | 1.00 | 3.53 (2.67, 4.67) | 0.22 |
| MV-adjusted | 1.00 | 1.81 (1.13, 2.90) | 1.00 | 1.49 (1.03, 2.13) | 0.32 | 1.00 | 1.44 (0.95, 2.17) | 1.00 | 1.73 (1.28, 2.33) | 0.25 |
|
| ||||||||||
| Genetic score of 29 SNPs | ||||||||||
|
| ||||||||||
| Any diuretic use | No | Yes | No | Yes | No | Yes | No | Yes | ||
|
| ||||||||||
| No. of Cases | 218 | 35 | 415 | 59 | 73 | 57 | 120 | 104 | ||
| Person-Years | 37698 | 1704 | 37670 | 1805 | 78292 | 13585 | 79313 | 12737 | ||
| Age-adjusted | 1.00 | 4.19 (2.81, 6.23) | 1.00 | 3.46 (2.56, 4.68) | 0.48 | 1.00 | 4.04 (2.82, 5.79) | 1.00 | 4.79 (3.65, 6.30) | 0.38 |
| MV-adjusted | 1.00 | 2.19 (1.40, 3.43) | 1.00 | 1.88 (1.34, 2.64) | 0.40 | 1.00 | 1.97 (1.34, 2.90) | 1.00 | 2.39 (1.77, 3.24) | 0.39 |
| Thiazide diuretic use | No | Yes | No | Yes | No | Yes | No | Yes | ||
|
| ||||||||||
| No. of Cases | 226 | 27 | 425 | 49 | 89 | 41 | 145 | 79 | ||
| Person-Years | 37914 | 1489 | 37871 | 1604 | 79905 | 11972 | 80613 | 11437 | ||
| Age-adjusted | 1.00 | 3.60 (2.33, 5.57) | 1.00 | 3.21 (2.32, 4.44) | 0.70 | 1.00 | 2.89 (1.98, 4.22) | 1.00 | 3.52 (2.65, 4.67) | 0.34 |
| MV-adjusted | 1.00 | 1.78 (1.10, 2.88) | 1.00 | 1.67 (1.17, 2.40) | 0.56 | 1.00 | 1.43 (0.96, 2.13) | 1.00 | 1.77 (1.30, 2.40) | 0.33 |
MV models were adjusted for age (continuous), BMI (continuous), menopause (yes or no), use of hormone therapy (never, past, or current), history of hypertension (yes or no), systolic and diastolic blood pressure (continuous), alcohol (continuous), total energy intake (continuous), and intake of sugar-sweetened soft drinks, meat, seafood, and dairy foods (continuous).