Figure 4.
Structure of the Oxytricha nova telomeric DNA d(GGGGTTTTGGGG) in the presence of different monovalent cations. The side views of the crystal structure in the presence of K+ (A), Na+ (D) and Tl+ (G) ions. A view shown down the central ion channel of the quadruplex in the presence of K+ (B), Na+ (E) and Tl+ (H). Schematic representations of the bi-molecular quadruplex showing positions of the monovalent cations in the central ion channel. K+ ions (C) and Tl+ (I) ions are sandwiched between G-quartets whereas Na+ (F) ions are located in plane with G-quartets. PDB entries (K+: IJPQ, Tl+: 2HBN and Na+: 1JB7).