Fig. 3.

Ghrelin stimulated SST release, while decreasing insulin and glucagon release, in a perfused pancreas model. Whole pancreases were perfused with 12 mmol/l glucose (control) and treated with 1 or 100 nmol/l ghrelin, and the secretion of SST (a, b), insulin (c, d) and glucagon (e, f) was measured. Mean hormone outputs were averaged over 5 min before addition of the test substance and during the final 5 min of test substance perfusion. Data are represented as means ± SEM. Significance was tested by one-way ANOVA with post hoc Tukey modification; n = 7; *p < 0.05, ***p < 0.001