Key effects of exercise training on pathways that influence IHL content
Plasma NEFA	• Increase in plasma NEFA uptake by skeletal muscle
	• Some evidence for decrease in fasting and/or postprandial plasma NEFA
Dietary TAG	• Increase in LPL-mediated TAG uptake by skeletal muscle
	• Decrease in HL-mediated TAG uptake by liver
DNL	• Decrease in plasma insulin, a key player for the activation of DNL
	• In diabetes, exercise can decrease plasma glucose and hence decrease DNL
	• Lower ACC and FAS protein content, indicative for decreased de novo lipolysis activity (rodent data)
VLDL metabolism	• Decrease in hepatic VLDL–ApoB-100 and VLDL–TAG secretion, possibly as a consequence of lower hepatic TAG accumulation
Mitochondrial oxidation	• Increase in hepatic CS, β-HAD and Cyt c, indicative for increases in hepatic mitochondrial content and oxidative phosphorylation (rodent data)