Fig. 2.

Release of LIGHT from platelets and PBMCs. (a) The spontaneous release of LIGHT in PRP from seven patients with type 2 diabetes mellitus (grey bars, Norwegian cohort) and six healthy controls (white bars). (b, c) The release of LIGHT in unstimulated PBMCs (white bars) and PBMCs stimulated with phytohaemagglutinin (PHA; 20 μg/ml, grey bars) after culturing for 20 h (b) and 48 h (c) in the same individuals as in (a). The Mann–Whitney U test was used to compare patients and healthy controls (a) and Wilcoxon signed rank test to compare PHA-stimulated and unstimulated cells (b, c). *p < 0.05 and **p < 0.01. DM, diabetic group