Table I.
Characteristics of patients with chronic atrial fibrillation
| Variable | N = 110 | TF(+) n = 16 |
TF(–) n = 94 |
FXIa(+) n = 16 |
FXIa(–) n = 94 |
FIXa(+) n = 28 |
FIXa(–) n = 81 |
|---|---|---|---|---|---|---|---|
| Age [years] | 63.0 (55.0; 70.0) | 60.0 (52.0; 67.8) | 63.0 (56.0; 70.3) | 57.0 (50.3; 69.8) | 63.5 (56.8; 70.0) | 61.5 (53.3; 66.8) | 64.0 (55.0; 71.5) |
| Male gender, n (%) | 57 (51.8) | 8 (50.0) | 49 (52.1) | 7 (43.8) | 50 (53.2) | 20 (71.4)* | 37 (45.7) |
| BMI [kg/m2] | 29.1 (26.6; 31.4) | 30.7 (26.9; 32.2) | 29.0 (26.3; 31.2) | 27.1 (25.1; 32.0) | 29.2 (26.8; 31.2) | 31.8 (26.4; 35.5)* | 28.4 (26.6; 30.6) |
| Hypertension, n (%) | 65 (59.1) | 4 (25.0)* | 61 (64.9) | 6 (37.5) | 59 (62.8) | 19 (67.9) | 46 (56.8) |
| CAD, n (%) | 15 (13.6) | 3 (18.8) | 12 (12.8) | 4 (25.0) | 11 (11.7) | 7 (25.0) | 8 (9.9) |
| Diabetes, n (%) | 6 (5.5) | 2 (12.5) | 4 (4.3) | 2 (12.5) | 4 (4.3) | 1 (3.6) | 5 (6.2) |
| Heart failure, n (%) | 20 (18.2) | 1 (6.3) | 19 (20.2) | 1 (6.3) | 19 (20.2) | 7 (25.0) | 13 (16.0) |
| Smoking, n (%) | 44 (40.0) | 2 (12.5)* | 42 (44.7) | 2 (12.5)* | 42 (44.7) | 10 (35.7) | 34 (42.0) |
| CHADS2 ≥ 2 points | 27 (24.5) | 3 (18.8) | 25 (25.5) | 4 (25.0) | 23 (24.5) | 7 (25.0) | 20 (24.7) |
| CHADS2 1 point | 47 (42.7) | 2 (12.5)* | 45 (47.9) | 2 (12.5)* | 45 (47.9) | 15 (53.6) | 32 (39.5) |
| CHA2DS2-VASc ≥ 2 points, n (%) | 64 (58.2) | 5 (31.3)* | 59 (62.8) | 6 (37.5) | 58 (61.7) | 16 (57.1) | 48 (59.3) |
| CHA2DS2-VASc 1 point, n (%) | 37 (33.6) | 9 (56.3)* | 28 (29.8) | 8 (50.0) | 29 (30.9) | 9 (32.1) | 27 (33.3) |
| Aspirin, n (%) | 35 (31.8) | 9 (56.2)* | 26 (27.7) | 12 (75.0)* | 23 (24.5) | 12 (42.9) | 22 (27.2) |
| Statin, n (%) | 53 (48.2) | 1 (6.3)* | 52 (55.3) | 4 (25.0) | 49 (52.1) | 10 (35.7) | 43 (53.1) |
| Total cholesterol [mM] | 5.05 (4.17; 5.62) | 5.01 (4.62; 5.89) | 5.05 (4.01; 5.61) | 4.83 (4.05; 5.49) | 5.08 (4.18; 5.65) | 5.25 (3.91; 5.87) | 5.03 (4.19; 5.59) |
| LDL cholesterol [mM] | 2.91 (2.36; 3.40) | 3.02 (2.51; 3.38) | 2.86 (2.36; 3.40) | 3.00 (2.34; 3.10) | 2.86 (2.38; 3.43) | 2.95 (2.22; 3.79) | 2.88 (2.41; 3.36) |
| HDL cholesterol [mM] | 1.46 (1.14; 1.70) | 1.61 (1.21; 1.74) | 1.44 (1.14; 1.69) | 1.56 (1.00; 1.69) | 1.45 (1.18; 1.71) | 1.46 (1.15; 1.72) | 1.45 (1.14; 1.70) |
| Triglycerides [mM] | 1.15 (0.74; 1.66) | 1.43 (0.64; 1.93) | 1.13 (0.75; 1.58) | 1.17 (0.62; 1.67) | 1.13 (0.75; 1.66) | 0.94 (0.67; 1.63) | 1.17 (0.78; 1.69) |
| Glucose [mM] | 4.90 (4.50; 5.20) | 4.95 (4.53; 5.40) | 4.87 (4.50; 5.20) | 4.85 (4.43; 5.30) | 4.90 (4.51; 5.20) | 4.85 (4.43; 5.08) | 4.90 (4.51; 5.25) |
| Creatinine [µM] | 70.7 (60.8; 80.3) | 72.5 (58.0; 85.8) | 70.7 (61.0; 79.7) | 62.5 (50.8; 84.0) | 70.7 (61.9; 80.3) | 69.5 (60.0; 79.8) | 69.5 (60.0; 79.8); |
| INR | 2.48 (2.25; 2.83) | 2.50 (2.20; 2.78) | 2.45 (2.25; 2.84) | 2.60 (2.39; 2.92) | 2.44 (2.20; 2.75) | 2.40 (2.08; 2.72) | 2.49 (2.30; 2.85) |
| VWF (%) | 210.5 (169.0; 240.3) | 271.0 (251.0; 279.0)* | 196.5 (168.0; 231.3) | 253.0 (192.8; 278.8)* | 205.5 (168.0; 235.3) | 222.0 (168.5; 235.8) | 202.0 (169.0; 245.5) |
| CRP [mg/l] | 2.96 (1.89; 4.44) | 2.35 (1.20; 4.13) | 3.01 (1.92; 4.70) | 2.23 (1.20; 4.13) | 3.01 (1.98; 4.51) | 3.12 (2.08; 5.29) | 2.98 (1.83; 4.42) |
| IL-6 [pg/ml] | 5.55 (4.40; 7.03) | 7.65 (5.50; 9.88)* | 5.40 (4.30; 6.70) | 6.30 (5.30; 9.33)* | 5.40 (4.30; 6.83) | 5.40 (4.23; 7.08) | 5.60 (4.45; 6.75) |
| LVEF (%) | 49.0 (41.2; 55.0) | 52.1 (41.5; 59.7) | 47.9 (40.9; 55.0) | 53.0 (43.3; 59.7) | 47.9 (40.4; 55.0) | 51.0 (42.4; 57.9) | 48.0 (40.8; 53.4) |
| LA [mm] | 43.0 (40.0; 46.0) | 44.5 (42.3; 52.8)* | 43.0 (40.0; 45.0) | 42.5 (38.5; 44.8) | 43.0 (40.0; 46.0) | 43.5 (40.0; 47.0) | 43.0 (40.5; 45.0) |
Values are presented as median and quartiles or as percentages.
*
Values of p < 0.05 versus a subgroup without the factor tested.