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. 2016 Jul 25;291(37):19364–19373. doi: 10.1074/jbc.M116.732347

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Paclitaxel increases presynaptic NMDAR activity in the spinal cord. A, representative recording traces and cumulative plots show the baseline and effect of bath application of 50 μm AP5 on the frequency and amplitude of mEPSCs of a lamina II neuron from a vehicle-treated rat. B, original traces and cumulative plots show the baseline and effect of AP5 on the frequency and amplitude of mEPSCs of a lamina II neuron recorded from a paclitaxel-treated rat. C, box/whisker plots show the baseline and effect of AP5 on the frequency and amplitude of mEPSCs in vehicle-treated rats (n = 8 neurons, 4 rats) and paclitaxel-treated (n = 12 neurons, 5 rats). *, p < 0.05 compared with the respective baseline control. #, p < 0.05 compared with baseline in the vehicle-treated group.