FIGURE 14.

Electrostatic complementarity of ASC PYD dimer and comparison with a previously proposed dimer. A, structural model of the ASC PYD dimer template used to create the fibrils shown in Fig. 10. Side chains of residues involved in the interaction are shown in color to differentiate the positive (blue) and negative (red) net charge. Both the interaction interface and the interfaces remaining at the other end of the domains show complementary charges, allowing for the polymerization of the fibril. B, comparison of our ASC PYD dimer (gray) with one proposed previously (red) (16). The first protomer of each dimer are aligned for clarity showing the different orientation of the remaining protomer in both dimer models.