Table 2. Multivariable logistic regression analysis of psychotropic medication type among veterans who were prescribed medication N=42 936.
| Characteristics | N (%) | Antidepressant | Anxiolytics | Antipsychotics | Prazosin | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N=39 563 (92.1%) | N=17 927 (41.8%) | N=8644 (20.1%) | N=10 144 (23.6%) | ||||||||||
| OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | ||
| Male (ref) | 39 220 (91.3) | ||||||||||||
| Female | 3716 (8.7) | NS | 1.18 | 1.10–1.27 | <0.001 | 0.68 | 0.62–0.75 | <0.0001 | 0.67 | 0.62–0.74 | <0.001 | ||
| Ethnicity | |||||||||||||
| White (ref) | 25 870 (60.3) | ||||||||||||
| Black | 5209 (12.1) | 1.25 | 1.10–1.41 | <0.001 | 0.62 | 0.58–0.66 | <0.001 | NS | 0.85 | 0.79–0.91 | <0.001 | ||
| Hispanic | 4267 (9.9) | 0.70 | 0.50–0.99 | 0.045 | 0.93 | 0.76–1.15 | 0.529 | NS | 1.47 | 1.18–1.83 | 0.001 | ||
| Asian | 1067 (2.5) | 0.92 | 0.73–1.15 | 0.466 | 0.84 | 0.73–0.95 | 0.008 | NS | 1.28 | 1.11–1.48 | 0.001 | ||
| Other (or unknown) | 6523 (15.2) | 1.04 | 0.95–1.14 | 0.379 | 0.87 | 0.72–1.06 | 0.161 | NS | 1.00 | 0.95–1.06 | 0.926 | ||
| Married (ref: not married) | 18 828 (43.9) | 1.12 | 1.04–1.20 | 0.003 | 1.06 | 1.02–1.10 | 0.008 | NS | 1.07 | 1.02–1.12 | 0.007 | ||
| Urban living (ref: rural) | 28 330 (66.3) | 0.90 | 0.83–0.97 | 0.008 | NS | 0.91 | 0.86–0.96 | <0.001 | NS | ||||
| Comorbid diagnosis | |||||||||||||
| Schizophrenia | 207 (0.5) | NS | 1.96 | 1.47–2.63 | <0.001 | 17.08 | 10.74–27.17 | <0.001 | NS | ||||
| Other psychosis | 647 (1.5) | 0.51 | 0.40–0.65 | <0.001 | NS | 14.60 | 11.72–18.17 | <0.001 | 1.31 | 1.11–1.56 | 0.002 | ||
| Bipolar | 1345 (3.1) | 0.37 | 0.32–0.44 | <0.001 | 1.66 | 1.48–1.85 | <0.001 | 7.39 | 6.52–8.37 | <0.001 | 1.24 | 1.09–1.40 | 0.001 |
| Anxiety disorder | 11 557 (26.9) | 1.11 | 1.02–1.21 | 0.020 | 1.69 | 1.62–1.77 | <0.001 | 1.20 | 1.13–1.27 | <0.001 | 1.07 | 1.02–1.13 | 0.008 |
| Major depression | 8919 (20.8) | 2.44 | 2.16–2.74 | <0.001 | 1.28 | 1.22–1.34 | <0.001 | 1.62 | 1.53–1.72 | <0.001 | 1.33 | 1.26–1.40 | <0.001 |
| Other depression | 19 016 (44.3) | 2.00 | 1.84–2.16 | <0.001 | 1.12 | 1.08–1.17 | <0.001 | 1.44 | 1.37–1.52 | <0.001 | 1.14 | 1.09–1.19 | <0.001 |
| Alcohol use disorder | 6422 (15.0) | 1.43 | 1.28–1.61 | <0.001 | 0.86 | 0.81–0.92 | <0.001 | 1.31 | 1.23–1.41 | <0.001 | 1.14 | 1.06–1.22 | <0.001 |
| Drug use disorder | 3487 (8.1) | NS | 1.16 | 1.08–1.26 | <0.001 | 1.95 | 1.79–2.12 | <0.001 | 1.29 | 1.19–1.41 | <0.001 | ||
| Personality disorder | 757 (1.8) | NS | 1.30 | 1.12–1.51 | 0.001 | 2.90 | 2.46–3.41 | <0.001 | NS | ||||
| No disability rating (ref) | 23 877 (66.1) | ||||||||||||
| Disability rating <50% | 6964 (16.2) | NS | 1.00 | 0.95–1.06 | 0.872 | 0.84 | 0.78–0.90 | <0.001 | 0.91 | 0.85–0.97 | 0.004 | ||
| Disability rating ≥50% | 7595 (17.7) | NS | 1.37 | 1.30–1.44 | <0.001 | 1.38 | 1.29–1.47 | <0.001 | 1.13 | 1.06–1.20 | <0.001 | ||
| Age | 30.75 ± 8.26 | NS | NS | 0.98 | 0.98–0.99 | <0.001 | NS | ||||||
| PCL scores | 58.32 ± 13.48 | ||||||||||||
| PCL re-experiencing* | NS | 1.13 | 1.10–1.17 | <0.001 | 1.28 | 1.23–1.32 | <0.001 | 1.46 | 1.43–1.52 | <0.001 | |||
| PCL avoidant* | NS | NS | NS | NS | |||||||||
| PCL numbing* | 1.17 | 1.12–1.23 | <0.001 | NS | 1.10 | 1.06–1.13 | <0.001 | 0.92 | 0.90–0.95 | <0.001 | |||
| PCL dysphoric arousal* | NS | 1.07 | 1.04–1.10 | <0.001 | 0.95 | 0.92–0.99 | 0.007 | NS | |||||
| PCL anxious arousal* | NS | 0.96 | 0.94–0.99 | 0.007 | NS | NS | |||||||
NS, not significant.
*
z-scores