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. 2016 Sep 9;6:32759. doi: 10.1038/srep32759

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Copyright © 2016, The Author(s)

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(a) Semi-quantitative RT-PCR analysis from corpus mucosa extract for intestinal goblet, absorptive and Paneth cell markers as well as HNF4α isoforms revealed expression for Muc2, sucrase-isomaltase (SI), lysozyme, cryptidin 1 Cdx2, Tff3, and P1 promoter-driven HNF4α isoforms in P90 gastric mucosa of Bmpr1a^ΔMES mice whereas no expression of these mRNAs was found in normal stomach (n = 4). P2 promoter-driven HNF4α isoform mRNA was found to be ubiquitously expressed in normal and Bmpr1a^ΔMES gastric mucosa. Jejunum mucosa served as a positive control. TBP was used as a reference gene. (b) Real time qPCR analysis of early gastric cancer genes expression were found to be deregulated in Bmpr1a^ΔMES mice. Mutant P90 gastric mucosa displayed a significant increase in Aurka and Sox9 mRNA as well as a significant decrease in Gkn2 mRNA expression levels compared with control mice (n = 6). Mann-Whitney; *p < 0.05. Jej, Jejunum.