Table 1. CAF markers and soluble factors gene expression changes in Bmpr1aΔMES mice.
| Gene Description | Gene Symbol | Fold | P Value |
|---|---|---|---|
| Wnt Pathway | |||
| Secreted frizzled-related protein 1 | sFrp1 | −2.34 | 0.038 |
| Dickkop homolog 1 | Dkk | −2.28 | NS |
| Wingless-type MMTV integration site family member 5a | Wnt5a | 1.08 | NS |
| Bmp pathway | |||
| Bone morphogenetic protein 2 | Bmp2 | −1.25 | NS |
| Bone morphogenetic protein 4 | Bmp4 | −1.21 | NS |
| Bone morphogenetic protein 7 | Bmp7 | −1.02 | NS |
| Noggin | Nog | −9.34 | 0.012 |
| Chordin | Chrd | −3.82 | 0.017 |
| Growth Factor | |||
| Hepatocyte growth factor | Hgf | 2.54 | 0.017 |
| Insulin-like growth factor | Igf | −1.46 | NS |
| CAF Markers | |||
| Fibroblast surface protein | Fsp1/S100A4 | 3.47 | 0.002 |
Fold change represents the ratio of mean expression values (control/mutant) derived for qPCR data. Negative values indicate reduction in Bmpr1aΔMES mice. NS = nonsignificant fold change (Mann-Whitney U test).