Table 4. Meta-analysis of association between CD147/EMMPRIN expression and tumor prognosis.
| OS |
PFS |
DSS |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No/case | meta-HR (95CI%) P* | I2 (P#) | No/case | meta-HR (95CI%) P* | I% (P#) | No/case | meta-HR (95CI%) P* | I2 (P#) | ||||
| Multivariate | ||||||||||||
| Total | 27/3933 | 1.92 (1.58–2.32) 0.000 | 66.4 (0.000) | 13/1845 | 2.32 (1.67–3.21) 0.000 | 56.3 (0.007) | 4/991 | 1.83 (1.27–2.65) 0.001 | 0.00 (0.458) | |||
| Solid tumor | 23/3563 | 1.73 (1.44–2.08) 0.000 | 60.7 (0.000) | 12/1792 | 2.26 (1.61–3.18) 0.000 | 58.5 (0.005) | 4/991 | 1.83 (1.27–2.65) 0.001 | 0.00 (0.458) | |||
| Nun-solid tumor | 4/370 | 3.72 (2.23–6.22) 0.000 | 36.6 (0.192) | 1/53 | 3.52 (1.18–10.5) 0.024 | 0 | ||||||
| Breast carcinoma | 5/695 | 2.92 (1.85–4.60) 0.000 | 5.00 (0.378) | 3/419 | 2.50 (1.63–3.83) 0.000 | 0.00 (0.846) | ||||||
| Bladder cancer | 3/333 | 2.32 (1.63–3.29) 0.000 | 0.00 (0.860) | |||||||||
| Gastric carcinoma | 3/878 | 1.33 (0.99–1.80) 0.060 | 62.0 (0.072) | |||||||||
| Colorectal cancer | 2/527 | 2.14 (1.38–4.26) 0.035 | 77.9 (0.033) | |||||||||
| Ovarian cancer | 3/326 | 1.57 (1.23–2.01) 0.000 | 0.00 (0.982) | 2/234 | 1.72 (1.23–2.40) 0.002 | 0.00 (0.833) | ||||||
| Osteosarcoma | 2/108 | 7.83 (3.18–19.27) 0.000 | 0.00 (0.852) | |||||||||
| Total publish bias | 0.05 (Begg’ test) | 0.007 (Egger’ test) | 0.300 (Begg’ test) | 0.259 (Egger’ test) | 0.734 (Begg’ test) | 0.469 (Egger’ test) | ||||||
| Univariate | ||||||||||||
| Total | 17/1880 | 1.98 (1.53–2.57) 0.000 | 89.3 (0.000) | 6/627 | 2.18 (1.30–3.63) 0.003 | 96.7 (0.000) | 1/40 | 5.81 (4.16–7.46) 0.037 | ||||
| Solid tumor | 15/1719 | 2.06 (1.57–2.70) 0.000 | 90.4 (0.000) | 6/627 | 2.18 (1.30–3.63) 0.003 | 96.7 (0.000) | 1/40 | 5.81 (4.16–7.46) 0.037 | ||||
| Nun-solid tumor | 2/161 | 1.34 (0.77–2.32) 0.300 | 2.90 (0.310) | 0 | 0 | |||||||
| Renal cell carcinoma | 3/202 | 1.87 (1.37–2.56) 0.000 | 70.9 (0.032) | 2/230 | 1.58 (1.34–1.85) 0.000 | 0.00 (0.91) | ||||||
| Lung Cancer | 3/393 | 1.16 (0.63–2.12) 0.630 | 74.1 (0.021) | — | — | |||||||
| Bladder carcinoma | 2/418 | 2.51 (1.46–4.33) 0.001 | 81.9 (0.019) | — | — | |||||||
| Total publish bias | 0.773 (Begg’ test) | 0.228 (Egger’ test) | −0.707 (Begg’ test) | −0.304 (Egger’ test) | ||||||||
P* present P for HR, P# present P for I2.