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. 2016 Sep 9;6:32822. doi: 10.1038/srep32822

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Ribbon diagram of the Pseudomonas aeruginosa LpxH (PaLpxH) shown in rainbow color (P2₁ crystal with Mn²⁺). Lipid X is depicted by green sticks and the Mn²⁺ ions are violet spheres. PaLpxH consists of a catalytic domain of approximately 180 residues (Met1–Leu118 and Val174–Leu240) and a helical insertion domain (HI domain) (α4–α7). (b) Surface representation of the PaLpxH. The structure is colored in red with different density based on the hydrophobicity scale³⁰. (c) Cross-sectional view of the PaLpxH focusing to hydrophobic cavity between the catalytic and HI domains. The 2-acyl chain of the lipid X is deeply buried in the cavity. d. Fo–Fc omit maps superposed with bound lipid X (cut off 3.5 σ).