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. 2016 Sep 9;6:32822. doi: 10.1038/srep32822

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Copyright © 2016, The Author(s)

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LpxH captures UDP-2,3-diacyl-GlcN and forms an ES complex in which the substrate is bound in a manner similar to that seen in the EP complex. The hydrolysis reaction occurs as in Fig. 5, whereas the hydrophobic surface of the HI domain of the EP complex is in contact with the inner membrane. The interactions between the HI domain and membrane surface induce a conformational change (or opening) in helix α6, which releases lipid X with concomitant embedding of the molecule.