Table 5.
Group | 1 | 2 | 3 | 4 |
---|---|---|---|---|
RGCs (number/mm2) On day 1 | 1952.16 ± 125.29 | 929.01 ± 135.00** | 1112.65 ± 164.10 | 1691.36 ± 237.57†† |
RGCs (number/mm2) On day 7 | 1737.23 ± 151.94 | 887.73 ± 158.18** | 941.89 ± 38.91 | 1389.02 ± 53.20†† |
In comparison of the control retina, 1 or 7 days following sham procedure (Sham; Group 1), after retinal ischemia plus 1 or 7 days of reperfusion and pretreatment with vehicle (I/R + Vehicle; Group 2), the number of fluorogold-immunolabeling retinal ganglion cells (RGCs) per field was significantly decreased (** P < 0.01). In contrast, this significant decrease was dose-dependently (with a less effect at 2.8 g/kg/day, I/R + CJDHW2.8; Group 3) and significantly (†† P < 0.01; at 4.2 g/kg/day, I/R + CJDHW4.2; Group 4) inhibited by pretreatment with CJDHW. The results are the mean ± SD (μm; n = 3)