Fig. 2.

Flexibility of Mergeomics in accommodating different datasets and study designs. a When a single disease association dataset is available, an MSEA-wKDA-visualization flow can be utilized. b When multiple disease association datasets are available, use a Meta-MSEA then wKDA flow is more appropriate. c When selected disease-associated genes or proteins are already identified, wKDA can be directly used. MSEA could also be run if additional association datasets are available, allowing for association testing in other diseases or cross-species validation