Table 3.
Genotype Frequencies for MTHFR, all cases (PD & PS)
| Polymorphism | Genotype frequencies | p-value | |||
|---|---|---|---|---|---|
| MTHFR c.677C > T | MTHFR c.1298A > C | No. of Cases (%)a | No. of Controls (%)a | Age-adjusted OR (95 % CI)b | |
| CC | 66 (43.7) | 136 (43.7) | 1 | ||
| CT | 68 (45.0) | 134 (43.1) | 1.0 (0.7–1.6) | 0.8 | |
| TT | 17 (11.3) | 41 (13.2) | 0.9 (0.5–1.6) | 0.6 | |
| AA | 60 (39.7) | 132 (42.2) | 1 | ||
| AC | 68 (45.0) | 137 (43.8) | 1.1 (0.7–1.7) | 0.7 | |
| CC | 23 (15.2) | 44 (14.1) | 1.2 (0.6–2.1) | 0.6 | |
| CC | AA | 16 (10.6) | 24 (7.7) | 1 | |
| CT | AC | 41 (27.2) | 67 (21.6) | 0.9 (0.4–2.0) | 0.8 |
| TT | CC | - | - | - | |
| CC | AC | 27 (17.9) | 69 (22.3) | 0.6 (0.3–1.3) | 0.2 |
| CC | CC | 23 (15.2) | 43 (13.9) | 0.8 (0.4–1.8) | 0.6 |
| CT | AA | 27 (17.9) | 66 (21.3) | 0.6 (0.3–1.3) | 0.2 |
| CT | CC | - | - | - | |
| TT | AA | 17 (11.3) | 41 (13.2) | 0.6 (0.3–1.5) | 0.3 |
| TT | AC | - | - | - | |
aDNA of 79 controls and 27 cases had been used up and were therefore not available and a few samples did not yield PCR products
b p-values were all >0.05