Fig. 1.

Gly injection reduced infarct size after focal ischemia in wild-type rats. Infarct size in the ipsilateral hemisphere was measured 3 days after stroke onset using TTC staining, then normalized to the contralateral hemisphere and expressed as a percentage. a Gly injection reduced infarct size in focal ischemia with 100-min MCA suture occlusion. Representative infarcts stained with TTC are shown. MCAo only, the animals received no any treatment; vehicle, the stroke animals were injected with vehicle; Pre + Post, the drug was injected i.p. immediately before stroke onset and at 2 h; Post twice, Gly was injected twice immediately and 3.5 h post-reperfusion; and Post once, Gly was injected one time immediately after reperfusion. b Bar graphs represent the statistic results. *P < 0.05 vs vehicle; ^# P < 0.05 vs MCAo only; n = 9–13/group